Delft Solids Case Study: Microbalance Validation for Pharmaceutical Research

Delft Solids Solutions is a contract research organisation specialising in powder and particle technology. The team studies how solid materials behave and are handled across industrial processes, supporting clients through experimental testing using advanced laboratory equipment.

With more than 40 years of experience, Delft Solids Solutions serves industries where high measurement accuracy is critical, including:

Pharmaceutical manufacturing
Chemical processing
Petrochemical applications
Automotive materials research

In these sectors, precise and repeatable mass data underpins research integrity, validation activities, and process improvement.

This case study focuses on microbalance validation for pharmaceutical research, where stable and accurate mass measurements are required over long-duration experiments.

Project Requirements

Delft Solids Solutions required a high-precision microbalance capable of supporting pharmaceutical research and validation work under demanding conditions.

Key requirements included:

Very small sample sizes (≈100 mg)
Microgram-level sensitivity maintained over long experiments
Stable performance during 6–72 hour test durations
Compatibility with powders, particles, and gels
Flexible configuration for multiple research projects

As a contract research organisation, the system needed to support a wide range of experimental setups without compromising accuracy or repeatability.

The CI Precision Solution

Delft Solids Solutions has used CI Precision’s MK2-M5 microbalance for more than four years to support advanced pharmaceutical research and validation activities.

The system is used across a broad range of experimental applications, including:

Sorption studies with CO₂ and H₂O
Desorption experiments using NH₃ and n-butylamine
TG-MS experiments for thermal analysis

Typical operating conditions include:

Sample size: ~100 mg
Particle size range: A few microns to several millimetres
Experiment duration: 6–72 hours
Operating environments: Multiple test gases

System Configuration and Performance

The MK2-M5 microbalance is supplied as a modular system, allowing researchers to configure the setup to suit specific experimental requirements while maintaining consistent performance.

Key benefits observed by Delft Solids Solutions include:

Microgram-level sensitivity maintained throughout long-duration tests
Stable operation under high-temperature and high-pressure conditions
Reliable, repeatable mass-change data across diverse applications
Reduced experimental error through consistent, validated measurements
Lower operational risk and improved confidence in research outcomes

The compact design and flexible configuration support efficient laboratory workflows while delivering trustworthy mass data for pharmaceutical research and validation.

Outcome

By implementing the MK2-M5 microbalance, Delft Solids Solutions achieved a robust and repeatable approach to microbalance validation for pharmaceutical research, supporting long-duration experiments across multiple applications with confidence in data integrity and measurement stability.

"Excellent support. CI Precision have been very willing to assist and provide fitting solutions."

(On recommending CIP to others) "Yes, support is excellent, and the accuracy and stability of the balance are very good."

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